By Frank J. Dixon (Ed.)
For 30 years, this esteemed serial has supplied scholars and researchers with the most recent info in Immunology. you could proceed to depend on Advances in Immunology to supply you with severe studies that research topics of important significance to the sphere via precis and overview of present wisdom and examine. The articles rigidity basic techniques, but additionally assessment the experimental methods. every one quantity of Advances in Immunology incorporates a topic index in addition to the contents of modern volumes. each one bankruptcy contains references. Researchers and scholars in microbiology, genetics and immunocology will use this worthwhile serial to stick up-to-date at the newest advances for future years. Key positive aspects * Advances in Immunology will preserve you trained on such widely outlined matters as: * Immunochemistry * Antibody synthesis * organic motion of antibodies * Immunological unresponsiveness * Mechanisms in innate and purchased immunity no longer related to antibodies * really expert immunological thoughts
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Subsequent receptor binding experiments demonstrated that OSM and LIF could bind to the same receptor on M 1 cells (Gearing and Bruce, 1992). l do not bind OSM. These differences were resolved by making use of the cDNA-directed L I F receptors expressed on transfected COS cells, B9 cells, and the LIF receptor in isolation as a soluble extracellular domain. OSM could bind the high-affinity component, but not the low-affinity component, of the L I F receptors on BS/hLIFR cells (like LIF, OSM did not appear to bind to untransfected B9 cells) and could not bind the low-affinity LIF receptor component on transfected COS cells or the soluble LIF receptor (Gearing and Bruce, 1992).
1990). IV. Roles for LIF in Disease: Inflammation and Cachexia? There have been two clinically interesting systems in which LIF has been demonstrated to be active: inflammation and cachexia. , 1989; Baumann and Wong, 1989), which causes the release of acute-phase plasma proteins (APPs). Together these results suggest a role for LIF as part o f t h e host response to inflammation. The production of APPs by L I F is also modulated by glucocorticoids. An acute-phase response follows LIF administration to mice: chronic administration led to an increase in serum haptoglobin ( H .
Sci. 88,2835. 75. , and Watson, J. D. (1987). The induction of lymphokine synthesis and cell growth in IL-3 dependent cell lines using Ag-Ab complexes. J . Immunol. 134,422. 76. Walsh, L. , Waldorf, H. , and Murphy, G. F. (1991). Human dermal mast cells contain and release tunior necrosis factor a , which induces leukocyte adhesion molecule 1. Proc. Natl. Acud. Sci. 88,4222. 77. Gordon, J. , Post, T. , Schulman, E. , and Galli, S. J. (1991). Characterization of mouse mast cell TNF-a induction in oitro and i n v i m , and demonstration that purified human lung mast cells contains TNF-a.
Advances in Immunology, Vol. 53 by Frank J. Dixon (Ed.)