Alex Avdeef's Absorption and Drug Development: Solubility, Permeability, PDF

By Alex Avdeef

ISBN-10: 1118057457

ISBN-13: 9781118057452

Explains tips to practice and research the result of the newest physicochemical methods

With this e-book as their advisor, readers have entry to all of the present info had to completely examine and appropriately verify a compound's pharmaceutical homes and their results on drug absorption. The booklet emphasizes oral absorption, explaining the entire physicochemical tools used this day to investigate drug applicants. additionally, the writer presents professional assistance to assist readers study the result of their reports in an effort to decide upon the main promising drug candidates.

This Second Edition has been completely up to date and revised, incorporating the entire most up-to-date study findings, equipment, and assets, including:

  • Descriptions and purposes of recent PAMPA versions, drawing on greater than thirty papers released by way of the author's examine group

  • Two new chapters reading permeability and Caco-2/MDCK and permeability and the blood-brain barrier

  • Expanded details and techniques to aid pKa determination

  • New examples explaining the therapy of virtually insoluble try compounds

  • Additional case reports demonstrating using the newest physicochemical techniques

  • New, revised, and multiplied database tables during the book

Well over 2 hundred drawings support readers larger comprehend tough thoughts and supply a visible consultant to complicated approaches. additionally, over 800 references function a gateway to the first literature within the box, facilitating additional study into the entire subject matters lined within the book.

This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar parts of analysis. it's also steered as a supplemental textual content for graduate classes in pharmaceutics.

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Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef

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