By Alex Avdeef
Explains tips to practice and research the result of the newest physicochemical methods
With this e-book as their advisor, readers have entry to all of the present info had to completely examine and appropriately verify a compound's pharmaceutical homes and their results on drug absorption. The booklet emphasizes oral absorption, explaining the entire physicochemical tools used this day to investigate drug applicants. additionally, the writer presents professional assistance to assist readers study the result of their reports in an effort to decide upon the main promising drug candidates.
This Second Edition has been completely up to date and revised, incorporating the entire most up-to-date study findings, equipment, and assets, including:
Descriptions and purposes of recent PAMPA versions, drawing on greater than thirty papers released by way of the author's examine group
Two new chapters reading permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded details and techniques to aid pKa determination
New examples explaining the therapy of virtually insoluble try compounds
Additional case reports demonstrating using the newest physicochemical techniques
New, revised, and multiplied database tables during the book
Well over 2 hundred drawings support readers larger comprehend tough thoughts and supply a visible consultant to complicated approaches. additionally, over 800 references function a gateway to the first literature within the box, facilitating additional study into the entire subject matters lined within the book.
This Second Edition is usually recommended as a reference for researchers in pharmaceutical R&D in addition to in agrochemical, environmental, and different similar parts of analysis. it's also steered as a supplemental textual content for graduate classes in pharmaceutics.
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Additional resources for Absorption and Drug Development: Solubility, Permeability, and Charge State
Absorption and Drug Development: Solubility, Permeability, and Charge State by Alex Avdeef