Read e-book online Amorphous Solid Dispersions: Theory and Practice (Advances PDF

By Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick

ISBN-10: 1493915975

ISBN-13: 9781493915972

ISBN-10: 1493948660

ISBN-13: 9781493948666

This quantity deals a finished consultant at the conception and perform of amorphous reliable dispersions (ASD) for dealing with demanding situations linked to poorly soluble medications. In twenty-three inclusive chapters, the publication examines thermodynamics and kinetics of the amorphous country and amorphous good dispersions, ASD applied sciences, excipients for stabilizing amorphous reliable dispersions reminiscent of polymers, and ASD production applied sciences, together with spray drying, sizzling soften extrusion, fluid mattress layering and solvent-controlled micro-precipitation expertise (MBP). each one expertise is illustrated by means of particular case reports. moreover, committed sections hide analytical instruments and applied sciences for characterization of amorphous reliable dispersions, the prediction of long term balance, and the improvement of compatible dissolution equipment and regulatory points. The ebook additionally highlights destiny applied sciences at the horizon, corresponding to supercritical fluid processing, mesoporous silica, KinetiSol®, and using non-salt-forming natural acids and amino acids for the stabilization of amorphous systems.

Amorphous good Dispersions: idea and perform is a important connection with pharmaceutical scientists attracted to constructing bioavailable and therapeutically potent formulations of poorly soluble molecules to be able to increase those applied sciences and improve larger medications for the future.

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Amorphous Solid Dispersions: Theory and Practice (Advances in Delivery Science and Technology) by Navnit Shah,Harpreet Sandhu,Duk Soon Choi,Hitesh Chokshi,A. Waseem Malick

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