Analytical Method Development and Stability Studies of by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu PDF

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

ISBN-10: 3656948895

ISBN-13: 9783656948896

Master's Thesis from the 12 months 2011 within the topic medication - Pharmacology, grade: 8.0, , direction: B.Pharm.,M.Pharm, language: English, summary: A opposite part excessive functionality liquid chromatographic technique (HPLC) has been built for the strategy improvement validation of Carvedilol in bulk and pharmaceutical formula by utilizing YMC PACK seasoned 4.6 X a hundred and fifty mm (5µm Particle size). The cellular part used to be Buffer: Acetonitrile: (70:30) and pH was once adjusted to two pumped at a stream cost of one ml/min and the eluents have been monitored at 320nm. Linearity was once acquired within the focus variety of 10-90 μg/ml. The retention time of Carvedilol was once came across to be 3.2 minute. the strategy used to be established for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been stumbled on to be 0.001 μg/ml and 0.011μg/ml respectively. the tactic used to be statistically confirmed and RSD was once came upon to be lower than 2% indicating excessive measure of accuracy and precision of the proposed HPLC approach. balance examine file printed that the drug is vulnerable for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is strong to thermal degradation. extra over the degradants have been good separated from its API. because of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC technique can be utilized for picking Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

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